Pierre Johannes Spies was born on 8 June 1985 in Pretoria and attended Afrikaanse Hoër Seunskool (Afrikaans High School for Boys, also known as Affies), a public school located in Pretoria. He attended alongside future Springbok team-mates Fourie du Preez and Wynand Olivier, professional rugby players Derick Kuün, Jacques-Louis Potgieter, Gerhard van den Heever, Adriaan Fondse and cricketers AB de Villiers, Heino Kuhn and Faf du Plessis. After school, he completed his first year in B.Sc. Construction Management at the University of Pretoria.
He married Juanne Weidemann, in December 2008.
He made his first class debut for the Blue Bulls in 2005 in a match against Griquas. He made his Super 12 debut against the Brumbies, becoming the youngest player ever to represent the Bulls.
Pierre made his Springbok debut against Australia in the 2006 Tri Nations Series.
In 2008 he won the award for South Africa’s Most Promising Player of the Year and Sportsman of the Year.
Pierre is currently playing for Montpellier in France.